BDBM595651 US11591328, Compound 4

SMILES Cn1cc(cn1)-c1cc(Oc2ccc(NC(=O)N3CCC4(CCC(F)(F)CC4)C3=O)nc2)ccn1

InChI Key InChIKey=BCDAHFZFGKOCPG-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 595651   

TargetMacrophage colony-stimulating factor 1 receptor(Human)
Xiamen Biotime Biotechnology

US Patent
LigandPNGBDBM595651(US11591328, Compound 4)
Affinity DataIC50: 8.5nMAssay Description:CSF1R: The specific operation is as follows: Set the concentration gradient of the test compound and dilute the test compound to the working concentr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2023
Entry Details
US Patent

TargetMacrophage colony-stimulating factor 1 receptor(Human)
Xiamen Biotime Biotechnology

US Patent
LigandPNGBDBM595651(US11591328, Compound 4)
Affinity DataIC50: 16nMAssay Description:Inhibition of CSF1R in human THP-1 cells assessed as reduction in AKT phosphorylation measured after 4 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Xiamen Biotime Biotechnology

US Patent
LigandPNGBDBM595651(US11591328, Compound 4)
Affinity DataIC50: 16nMAssay Description:c-Kit, PDGFRα, PDGFRβ, FLT-3:Add 5 μL of compound (10% DMSO) at 5 times the final concentration of the reaction to a 384-well plate. A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2023
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor alpha(Human)
Xiamen Biotime Biotechnology

US Patent
LigandPNGBDBM595651(US11591328, Compound 4)
Affinity DataIC50: 40nMAssay Description:c-Kit, PDGFRα, PDGFRβ, FLT-3:Add 5 μL of compound (10% DMSO) at 5 times the final concentration of the reaction to a 384-well plate. A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2023
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Xiamen Biotime Biotechnology

US Patent
LigandPNGBDBM595651(US11591328, Compound 4)
Affinity DataIC50: 783nMAssay Description:c-Kit, PDGFRα, PDGFRβ, FLT-3:Add 5 μL of compound (10% DMSO) at 5 times the final concentration of the reaction to a 384-well plate. A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2023
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Xiamen Biotime Biotechnology

US Patent
LigandPNGBDBM595651(US11591328, Compound 4)
Affinity DataIC50: 1.00E+4nMAssay Description:c-Kit, PDGFRα, PDGFRβ, FLT-3:Add 5 μL of compound (10% DMSO) at 5 times the final concentration of the reaction to a 384-well plate. A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2023
Entry Details
US Patent