BDBM597774 US11608319, Compound 20::US11608319, Compound 21

SMILES NC[C@H](C(=O)Nc1ccc(cc1)-c1cn[nH]c1)c1ccccc1

InChI Key InChIKey=WNFAWYDESPZZIJ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 597774   

TargetRho-associated protein kinase 1(Human)
Industrial Technology Research Institute

US Patent
LigandPNGBDBM597774(US11608319, Compound 21 | US11608319, Compound 20)
Affinity DataIC50: 5.5nMAssay Description:Table 2: Inhibitory effect of each compound synthesized above on Rho-associated protein kinase (ROCK) was tested.Method 1. 10 mM test compound was di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
Go to US Patent

TargetRho-associated protein kinase 1(Human)
Industrial Technology Research Institute

US Patent
LigandPNGBDBM597774(US11608319, Compound 21 | US11608319, Compound 20)
Affinity DataIC50: 550nMAssay Description:Table 2: Inhibitory effect of each compound synthesized above on Rho-associated protein kinase (ROCK) was tested.Method 1. 10 mM test compound was di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
Go to US Patent

TargetMyosin light chain kinase family member 4(Human)
Industrial Technology Research Institute

US Patent
LigandPNGBDBM597774(US11608319, Compound 21 | US11608319, Compound 20)
Affinity DataIC50: 55nMAssay Description:Table 4: Assay for Inhibitory Effect on Myosin Light Chain Kinase 4 (MYLK-4). The experimental procedure referred to the LanthaScreen Eu Kinase Bindi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
Go to US Patent

TargetMyosin light chain kinase family member 4(Human)
Industrial Technology Research Institute

US Patent
LigandPNGBDBM597774(US11608319, Compound 21 | US11608319, Compound 20)
Affinity DataIC50: 550nMAssay Description:Table 4: Assay for Inhibitory Effect on Myosin Light Chain Kinase 4 (MYLK-4). The experimental procedure referred to the LanthaScreen Eu Kinase Bindi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
Go to US Patent