BDBM598027 Tetrahydro-2H-pyran-4-yl(8-amino-7- fluoro-6-(8-methyl-2,3-dihydro-1H- pyrido[2,3-b][1,4]oxazin-7- yl)isoquinolin-3-yl)carbamate::US11612606, Compound 401

SMILES Cc1c2NCCOc2ncc1-c1cc2cc(NC(=O)OC3CCOCC3)ncc2c(N)c1F

InChI Key InChIKey=MXQDOIPMFYATOE-UHFFFAOYSA-N

Data  1 KI  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 598027   

LigandChemical structure of BindingDB Monomer ID 598027BDBM598027(US11612606, Compound 401 | Tetrahydro-2H-pyran-4-y...)
Affinity DataKi:  0.0190nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 598027BDBM598027(US11612606, Compound 401 | Tetrahydro-2H-pyran-4-y...)
Affinity DataEC50:  39nMAssay Description:Inhibition of HPK1 in primary human Pan T cells assessed as increase in IL-2 secretion pretreated for 30 mins followed by incubation with anti-CD3/an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 598027BDBM598027(US11612606, Compound 401 | Tetrahydro-2H-pyran-4-y...)
Affinity DataIC50: 97nMAssay Description:Inhibition of HPK1 in human Jurkat cells assessed as inhibition of anti-CD3/anti-CD28-induced SLP76 phosporylation at Ser376 residue incubated for 30...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetLymphocyte cytosolic protein 2(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 598027BDBM598027(US11612606, Compound 401 | Tetrahydro-2H-pyran-4-y...)
Affinity DataIC50: 97nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent