BDBM601044 3,5-dichloro-2-(triazol-1-yl)-4-(trifluoromethyl)pyridine::US11634391, Compound 307

SMILES FC(F)(F)c1c(Cl)cnc(c1Cl)-n1ccnn1

InChI Key InChIKey=IWICKJUITQVJQR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 601044   

TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
Ucl Business

US Patent
LigandPNGBDBM601044(3,5-dichloro-2-(triazol-1-yl)-4-(trifluoromethyl)p...)
Affinity DataIC50: 8.10nMAssay Description:An Echo liquid handler was used to acoustically dispense 500 nL of compounds into dry Greiner 384-well plates (catalog #781076), followed by 25 μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2023
Entry Details
Go to US Patent

TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
Ucl Business

US Patent
LigandPNGBDBM601044(3,5-dichloro-2-(triazol-1-yl)-4-(trifluoromethyl)p...)
Affinity DataIC50: 7.5nMAssay Description:Inhibition of human Notum (S81 to T451 residues) Cys330Ser mutant expressed in HEK293S cells using OPTS as substrate incubated for 40 mins by fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed