BDBM601290 (3R)-N-[(2S)-2-(dimethylamino)-3-(1H-indazol-1-yl)propyl]-3-phenylbutanamide ::US11634396, Compound 228

SMILES C[C@H](CC(=O)NC[C@H](Cc1ccc2n(ncc2c1)S(=O)(=O)c1ccc(C)cc1)N(C)C)c1ccccc1

InChI Key InChIKey=KPJGPMGJMCWANT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 601290   

TargetKappa-type opioid receptor(Human)
Epiodyne

US Patent
LigandPNGBDBM601290((3R)-N-[(2S)-2-(dimethylamino)-3-(1H-indazol-1-yl)...)
Affinity DataIC50: 300nMAssay Description:KOR β-Arrestin Agonist and Antagonist assays were preformed using the Tango OPRK1-bla U2OS cells from Invitrogen and purchased from ThermoFisher...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2023
Entry Details
US Patent

TargetMu-type opioid receptor(Human)
Epiodyne

US Patent
LigandPNGBDBM601290((3R)-N-[(2S)-2-(dimethylamino)-3-(1H-indazol-1-yl)...)
Affinity DataIC50: 3.00E+3nMAssay Description:CHO Tag-lite human mOR stable cell line from Cisbio (NCBI accession number: NM_000914.3, Bedford, Mass.) were seeded and grown to approximately 80% c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2023
Entry Details
US Patent