BDBM6028 2-(tert-Butoxycarbonylamino)-N-(4-{[3-ethyl-4-oxo-1-(2,4,6-trichlorophenyl)-4,5-dihydro-1H-pyrazolo[3,4-d]-pyrimidin-6-yl]methyl}phenyl)acetamide::pyrazolo[3,4-d]pyrimidin-4-one deriv. 24b::tert-butyl N-{[(4-{[3-ethyl-4-oxo-1-(2,4,6-trichlorophenyl)-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-6-yl]methyl}phenyl)carbamoyl]methyl}carbamate

SMILES CCc1nn(-c2c(Cl)cc(Cl)cc2Cl)c2nc(Cc3ccc(NC(=O)CNC(=O)OC(C)(C)C)cc3)[nH]c(=O)c12

InChI Key InChIKey=AOPVKMUMEMDUCK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 6028   

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Bristol-Myers Squibb

LigandPNGBDBM6028(2-(tert-Butoxycarbonylamino)-N-(4-{[3-ethyl-4-oxo-...)
Affinity DataIC50: 1.70E+3nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Bristol-Myers Squibb

LigandPNGBDBM6028(2-(tert-Butoxycarbonylamino)-N-(4-{[3-ethyl-4-oxo-...)
Affinity DataIC50: 16nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2005
Entry Details Article
PubMed
LigandPNGBDBM6028(2-(tert-Butoxycarbonylamino)-N-(4-{[3-ethyl-4-oxo-...)
Affinity DataIC50: 180nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2005
Entry Details Article
PubMed