BDBM605424 US11672785, Compound C

SMILES C[C@@H]1Cc2c([nH]c3ccccc23)[C@H](N1CC(C)(C)F)c1ccc(OCCN2CC(CF)C2)cc1

InChI Key InChIKey=IPBQTKXTHVMANC-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 605424   

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM605424(US11672785, Compound C | US20250114338, Example 15...)
Affinity DataEC50:  0.335nMAssay Description:All of the exemplary Formula I compounds in Tables 1 and 2 were tested for binding to ERa (Estrogen Receptor alpha) and biological activity according...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2025
Entry Details
US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM605424(US11672785, Compound C | US20250114338, Example 15...)
Affinity DataIC50: 1.35nMAssay Description:Compounds were screened for their ability to displace a fluorescent labelled tracer ERβ ligand via time resolved fluorescent energy transfer usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
US Patent