BDBM605445 (R)-6-(2-aminopyrimidin-5-yl)-4-((1- phenylethyl)amino)quinoline-3- carbonitrile::US11673876, Compound 53R

SMILES C[C@@H](Nc1c(cnc2ccc(cc12)-c1cnc(N)nc1)C#N)c1ccccc1

InChI Key InChIKey=UQTJNUFTALPBOP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 605445   

LigandPNGBDBM605445((R)-6-(2-aminopyrimidin-5-yl)-4-((1- phenylethyl)a...)
Affinity DataIC50: 200nMAssay Description:Z′-LYTE Assay Conditions: Test Compounds: The Test Compounds are screened in 1% DMSO (final) in the well. For 10 point titrations, 3-fold seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2023
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Mekanistic Therapeutics

US Patent
LigandPNGBDBM605445((R)-6-(2-aminopyrimidin-5-yl)-4-((1- phenylethyl)a...)
Affinity DataIC50: 11nMAssay Description:Z′-LYTE Assay Conditions: Test Compounds: The Test Compounds are screened in 1% DMSO (final) in the well. For 10 point titrations, 3-fold seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2023
Entry Details
Go to US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Mekanistic Therapeutics

US Patent
LigandPNGBDBM605445((R)-6-(2-aminopyrimidin-5-yl)-4-((1- phenylethyl)a...)
Affinity DataIC50: 110nMAssay Description:Z′-LYTE Assay Conditions: Test Compounds: The Test Compounds are screened in 1% DMSO (final) in the well. For 10 point titrations, 3-fold seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2023
Entry Details
Go to US Patent