BDBM608819 US11702411, Compound 2::US11702411, Example 2

SMILES N[C@@H]1CCCC11CCN(CC1)c1ncc(nc1CO)-c1cccc(Cl)c1Cl

InChI Key InChIKey=GXBNLFAOIREUSN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 608819   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Revolution Medicines

US Patent
LigandPNGBDBM608819(US11702411, Example 2 | US11702411, Compound 2)
Affinity DataIC50: 88nMAssay Description:The inhibition of SHP2 by compounds of the present disclosure (concentrations varying from 0.00005-10 μM) was monitored using an assay in which ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Revolution Medicines

US Patent
LigandPNGBDBM608819(US11702411, Example 2 | US11702411, Compound 2)
Affinity DataIC50: 275nMAssay Description:The inhibition of SHP2 by compounds of the present disclosure (concentrations varying from 0.00005-10 μM) was monitored using an assay in which ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent