BDBM60887 BDBM50392248::US9200020, Table 3, Compound 2B

SMILES COC(=O)CCN(CCn1cnc2c1nc[nH]c2=O)CCP(O)(O)=O

InChI Key InChIKey=OPKZIZSNFJBJNK-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 60887   

TargetHypoxanthine-guanine-xanthine phosphoribosyltransferase(Plasmodium falciparum)
The University of Queensland

US Patent
LigandPNGBDBM60887(US9200020, Table 3, Compound 2B | BDBM50392248)
Affinity DataKi:  100nM ΔG°:  -9.93kcal/moleT: 2°CAssay Description:The [3H]-hypoxanthine growth inhibition assay (Desjardins et al., 1979 Antimicrobial Agents Chemother 16: 710-718) was used to evaluate the in vitro ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2016
Entry Details
Go to US Patent

TargetHypoxanthine phosphoribosyltransferase(Plasmodium vivax)
The University of Queensland

US Patent
LigandPNGBDBM60887(US9200020, Table 3, Compound 2B | BDBM50392248)
Affinity DataKi:  2.10E+4nM ΔG°:  -6.63kcal/moleT: 2°CAssay Description:The [3H]-hypoxanthine growth inhibition assay (Desjardins et al., 1979 Antimicrobial Agents Chemother 16: 710-718) was used to evaluate the in vitro ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2016
Entry Details
Go to US Patent

TargetHypoxanthine-guanine phosphoribosyltransferase(Human)
The University of Queensland

US Patent
LigandPNGBDBM60887(US9200020, Table 3, Compound 2B | BDBM50392248)
Affinity DataKi: >2.00E+5nM ΔG°: >-5.25kcal/moleT: 2°CAssay Description:The [3H]-hypoxanthine growth inhibition assay (Desjardins et al., 1979 Antimicrobial Agents Chemother 16: 710-718) was used to evaluate the in vitro ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2016
Entry Details
Go to US Patent

TargetHypoxanthine-guanine phosphoribosyltransferase(Human)
The University of Queensland

US Patent
LigandPNGBDBM60887(US9200020, Table 3, Compound 2B | BDBM50392248)
Affinity DataKi: >2.00E+5nMAssay Description:Inhibition of human HGPRT using Prib-PP as substrate by spectrophotometric assay in presence of guanineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed