BDBM608978 US11702409, Example 62a::US11702409, Example 62b

SMILES COC(=O)c1ccc(cc1)-c1nn(C2CC3(C2)CN(C3)C(=O)OC(C)(C)C)c(C)c1-c1c(Cl)c(C)cc2n(ncc12)S(=O)(=O)c1ccc(C)cc1

InChI Key InChIKey=KCPYBNDWJPSAGF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 608978   

TargetGTPase KRas [G12C](Human)
Novartis

US Patent
LigandPNGBDBM608978(US11702409, Example 62a | US11702409, Example 62b)
Affinity DataIC50: 45nMAssay Description:Assays were run using 384-well plates (781207/Greiner) in which one column was designated as the high signal (no inhibition) control, and contained D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent

TargetGTPase KRas [G12C](Human)
Novartis

US Patent
LigandPNGBDBM608978(US11702409, Example 62a | US11702409, Example 62b)
Affinity DataIC50: 1.93E+4nMAssay Description:Assays were run using 384-well plates (781207/Greiner) in which one column was designated as the high signal (no inhibition) control, and contained D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent