BDBM609991 1-N'-(4-fluorophenyl)-1-N- [4-[6-methoxy-7-(3- morpholin- 4-ylpropoxy)pyrido[3,2- d]pyrimidin-4- yl]oxyphenyl]cyclopropane- 1,1-dicarboxamide::US11708367, Compound 65

SMILES COc1nc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3)ncnc2cc1OCCCN1CCOCC1

InChI Key InChIKey=QTPVSVVFIRRETN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 609991   

TargetTyrosine-protein kinase receptor UFO [473-894](Human)
Exelixis

US Patent
LigandPNGBDBM609991(US11708367, Compound 65 | 1-N'-(4-fluorophenyl)-1-...)
Affinity DataIC50: 55nMAssay Description:Human Axl (residues H473-A894 with Q764R, 161 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 μM KKSRGDYMTMQIG (SEQ ID NO. 43), 10 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2023
Entry Details
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TargetTyrosine-protein kinase Mer [557-882](Human)
Exelixis

US Patent
LigandPNGBDBM609991(US11708367, Compound 65 | 1-N'-(4-fluorophenyl)-1-...)
Affinity DataIC50: 10nMAssay Description:Human Mer (residues R557-E882 with H628Q and R794A, 0.7 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 30 mM NaCl, 250 μM GGMEDIYFEFMGGKK...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2023
Entry Details
Go to US Patent

LigandPNGBDBM609991(US11708367, Compound 65 | 1-N'-(4-fluorophenyl)-1-...)
Affinity DataIC50: 55nMAssay Description:Human KDR (residues K790-V1356, 55 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.33 mg/mL myelin basic protein, 10 mM magnesium acetate, an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2023
Entry Details
Go to US Patent