BDBM610196 1-{(S)-4-[4-(2-Cyclopropyl-pyrimidin-5-yl)-2-trifluoromethyl-thiazol-5-yl]-2-hydroxymethyl-piperazin-1-yl}-2-(3,5-di methyl-[1,2,4]triazol-1-yl)-ethanone::US10053457, Example 8

SMILES Cc1nc(C)n(CC(=O)N2CCN(C[C@H]2CO)c2sc(nc2-c2cnc(nc2)C2CC2)C(F)(F)F)n1

InChI Key InChIKey=ZGISBRGPKNASOI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 610196   

TargetC-X-C chemokine receptor type 3(Human)
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM610196(US10053457, Example 8 | 1-{(S)-4-[4-(2-Cyclopropyl...)
Affinity DataIC50: 10nMAssay Description:The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2023
Entry Details
Go to US Patent

TargetC-X-C chemokine receptor type 3(Human)
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM610196(US10053457, Example 8 | 1-{(S)-4-[4-(2-Cyclopropyl...)
Affinity DataIC50: 3.20E+3nMAssay Description:Stock solutions of test compounds are made up at a concentration of 10 mM in DMSO, and serially diluted in PBS containing 0.5% BSA to concentrations ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2023
Entry Details
Go to US Patent