BDBM610480 N-(4-(4,4-Difluoropiperidin-1-yl)pyridin-3-yl)imidazo[1,2-b]pyridazine-8-carboxamide::US10774086, Example 28

SMILES FC1(F)CCN(CC1)c1ccncc1NC(=O)c1ccnn2ccnc12

InChI Key InChIKey=IQZQCERNFAXKFQ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 610480   

TargetGlycogen synthase kinase-3 alpha(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM610480(US10774086, Example 28 | N-(4-(4,4-Difluoropiperid...)
Affinity DataIC50: 2nMAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2023
Entry Details
US Patent

TargetGlycogen synthase kinase-3 alpha(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM610480(US10774086, Example 28 | N-(4-(4,4-Difluoropiperid...)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of full length GST-tagged human recombinant GSK3-alpha using FL-KRREILSRRP[ps]ERYR-NH2 as substrate incubated for 20 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM610480(US10774086, Example 28 | N-(4-(4,4-Difluoropiperid...)
Affinity DataIC50: 4.60nMAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2023
Entry Details
US Patent

TargetMicrotubule-associated protein tau(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM610480(US10774086, Example 28 | N-(4-(4,4-Difluoropiperid...)
Affinity DataIC50: 140nMAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2023
Entry Details
US Patent