BDBM613499 3-[(2- cyanocyclopropanecarbonyl) amino]-1-[4-(cyanomethyl)-3-fluoro- 1-[(2-fluoro-5-hydroxy-4- phenyl-phenyl)methyl]-4- piperidyl]pyrazole-4- carboxamide::US11731943, Example 240

SMILES NC(=O)c1cn(nc1NC(=O)C1CC1C#N)C1(CC#N)CCN(Cc2cc(O)c(cc2F)-c2ccccc2)CC1F

InChI Key InChIKey=CWJRRAHESFARQA-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 613499   

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandPNGBDBM613499(US11731943, Example 240 | 3-[(2- cyanocyclopropane...)
Affinity DataKi:  0.190nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandPNGBDBM613499(US11731943, Example 240 | 3-[(2- cyanocyclopropane...)
Affinity DataKi:  0.290nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
US Patent