BDBM613511 US11731943, Example 252::methyl N-[4-carbamoyl-1-[4- (cyanomethyl)-1-[[4-(2- ethylthiazol-4- yl)phenyl]methyl]-3-fluoro-4- piperidyl]pyrazol-3-yl]carbamate

SMILES CCc1nc(cs1)-c1ccc(CN2CCC(CC#N)(C(F)C2)n2cc(C(N)=O)c(NC(=O)OC)n2)cc1

InChI Key InChIKey=VXBWIIVYWDIMGW-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 613511   

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandPNGBDBM613511(US11731943, Example 252 | methyl N-[4-carbamoyl-1-...)
Affinity DataKi:  0.300nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandPNGBDBM613511(US11731943, Example 252 | methyl N-[4-carbamoyl-1-...)
Affinity DataKi:  0.520nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
US Patent