BDBM613535 1-[1-(cyanomethyl)-4-[4-(2- furyl)anilino]cyclohexyl]-3- (cyclopropanecarbonylamino) pyrazole-4-carboxamide::US11731943, Example 276

SMILES NC(=O)c1cn(nc1NC(=O)C1CC1)C1(CC#N)CCC(CC1)Nc1ccc(cc1)-c1ccco1

InChI Key InChIKey=WBRBIAYHKJVDLM-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 613535   

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandPNGBDBM613535(US11731943, Example 276 | 1-[1-(cyanomethyl)-4-[4-...)
Affinity DataKi:  0.25nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandPNGBDBM613535(US11731943, Example 276 | 1-[1-(cyanomethyl)-4-[4-...)
Affinity DataKi:  2.20nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
US Patent