BDBM613543 US11731943, Example 284::methyl N-[4-carbamoyl-1-[4- (cyanomethyl)-3-fluoro-1-[(3- hydroxy-4-vinyl-phenyl)methyl]- 4-piperidyl]pyrazol-3- yl]carbamate

SMILES COC(=O)Nc1nn(cc1C(N)=O)C1(CC#N)CCN(Cc2ccc(C=C)c(O)c2)CC1F

InChI Key InChIKey=ZEJVWJWOFCQCIO-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 613543   

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandPNGBDBM613543(US11731943, Example 284 | methyl N-[4-carbamoyl-1-...)
Affinity DataKi:  0.300nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandPNGBDBM613543(US11731943, Example 284 | methyl N-[4-carbamoyl-1-...)
Affinity DataKi:  0.5nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
US Patent