BDBM613552 US11731943, Example 293::methyl N-[4-carbamoyl-1-[4- (cyanomethyl)-3-fluoro-1-[(3- fluoro-5-hydroxy- phenyl)methyl]-4- piperidyl]pyrazol-3-yl]carbamate

SMILES COC(=O)Nc1nn(cc1C(N)=O)C1(CC#N)CCN(Cc2cc(O)cc(F)c2)CC1F

InChI Key InChIKey=GOUBQGWJOXHKNQ-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 613552   

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandPNGBDBM613552(US11731943, Example 293 | methyl N-[4-carbamoyl-1-...)
Affinity DataKi:  0.300nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandPNGBDBM613552(US11731943, Example 293 | methyl N-[4-carbamoyl-1-...)
Affinity DataKi:  0.340nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
US Patent