BDBM613984 US11739090, Compound 7B

SMILES Nc1nccc2c(nn(-c3ccc(Oc4ccccc4)cc3)c12)[C@H]1CCCN(C1)C(=O)C=C

InChI Key InChIKey=BIRLBQULISTSMZ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 613984   

TargetEpidermal growth factor receptor(Human)
Jumbo Drug Bank

US Patent
LigandPNGBDBM613984(US11739090, Compound 7B)
Affinity DataIC50: 33.3nMAssay Description:1. Reaction conditions: buffer conditions: 20 mM HEPES (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/mL BSA, 0.1 mm Na3VO4, 2 mm DTT, 1% DM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2023
Entry Details
Go to US Patent

TargetTyrosine-protein kinase ITK/TSK(Human)
Jumbo Drug Bank

US Patent
LigandPNGBDBM613984(US11739090, Compound 7B)
Affinity DataIC50: 1.45E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2023
Entry Details
Go to US Patent

TargetTyrosine-protein kinase Tec(Human)
Jumbo Drug Bank

US Patent
LigandPNGBDBM613984(US11739090, Compound 7B)
Affinity DataIC50: 3.74nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2023
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Jumbo Drug Bank

US Patent
LigandPNGBDBM613984(US11739090, Compound 7B)
Affinity DataIC50: 0.930nMAssay Description:1. Reaction conditions: buffer conditions: 20 mM HEPES (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/mL BSA, 0.1 mm Na3VO4, 2 mm DTT, 1% DM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2023
Entry Details
Go to US Patent