BDBM616084 US20230271964, Example 1-41::US20230271964, Example 1-48

SMILES Cc1cc(cc(CO)n1)-c1c(nc(N)n2c1nn(Cc1nccn1C)c2=O)-c1ccccc1

InChI Key InChIKey=PTHHJLCULHXTNZ-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 616084   

TargetAdenosine receptor A2a(Human)
Astrazeneca

US Patent
LigandPNGBDBM616084(US20230271964, Example 1-41 | US20230271964, Examp...)
Affinity DataKi:  0.794nMAssay Description:Inhibition binding assays were performed using 0.2 µg of membranes prepared from HEK293 cells infected with BacMam human adenosine A2A receptor or 1....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2023
Entry Details
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TargetAdenosine receptor A2a(Human)
Astrazeneca

US Patent
LigandPNGBDBM616084(US20230271964, Example 1-41 | US20230271964, Examp...)
Affinity DataKi:  1.26nMAssay Description:Inhibition binding assays were performed using 0.2 µg of membranes prepared from HEK293 cells infected with BacMam human adenosine A2A receptor or 1....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2023
Entry Details
Go to US Patent

TargetAdenosine receptor A1(Human)
Astrazeneca

US Patent
LigandPNGBDBM616084(US20230271964, Example 1-41 | US20230271964, Examp...)
Affinity DataKi:  63.1nMAssay Description:Inhibition binding assays were performed using 0.2 µg of membranes prepared from HEK293 cells infected with BacMam human adenosine A2A receptor or 1....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2023
Entry Details
Go to US Patent

TargetAdenosine receptor A1(Human)
Astrazeneca

US Patent
LigandPNGBDBM616084(US20230271964, Example 1-41 | US20230271964, Examp...)
Affinity DataKi:  158nMAssay Description:Inhibition binding assays were performed using 0.2 µg of membranes prepared from HEK293 cells infected with BacMam human adenosine A2A receptor or 1....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2023
Entry Details
Go to US Patent