BDBM619181 US20230295119, Compound 130

SMILES COc1c(Nc2cc(Nc3ccc(CS(C)(=O)=O)cn3)ncc2C(=O)C2CC2)cccc1-c1ncn(C)n1

InChI Key InChIKey=WRLMMARWOGRJBC-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 619181   

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Gossamer Bio Services

US Patent
LigandPNGBDBM619181(US20230295119, Compound 130)
Affinity DataIC50: 5nMAssay Description:Compounds described herein were tested for the ability to inhibit activity of human JAK1, JAK2 and JAK3, which was achieved using TR-FRET assays. Bri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Gossamer Bio Services

US Patent
LigandPNGBDBM619181(US20230295119, Compound 130)
Affinity DataIC50: 500nMAssay Description:Compounds described herein were tested for the ability to inhibit activity of human JAK1, JAK2 and JAK3, which was achieved using TR-FRET assays. Bri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Gossamer Bio Services

US Patent
LigandPNGBDBM619181(US20230295119, Compound 130)
Affinity DataIC50: 500nMAssay Description:Compounds described herein were tested for the ability to inhibit activity of human JAK1, JAK2 and JAK3, which was achieved using TR-FRET assays. Bri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Gossamer Bio Services

US Patent
LigandPNGBDBM619181(US20230295119, Compound 130)
Affinity DataIC50: 500nMAssay Description:Compounds described herein were tested for the ability to inhibit activity of human JAK1, JAK2 and JAK3, which was achieved using TR-FRET assays. Bri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent