BDBM619648 US20230295142, Compound 4::US20230295142, Compound 9

SMILES O=C2CN(c1ccccc1)C(=O)N2Cc4ccc(c3nnc(C(F)F)o3)cn4

InChI Key InChIKey=HLPZQOZQRLVDGO-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 619648   

TargetHistone deacetylase 6(Human)
Chong Kun Dang Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 619648BDBM619648(US12570646, Compound 4 | US20230295142, Compound 4)
Affinity DataIC50: 99nMAssay Description:Cell-based activity under Prompt Conditions. Rat or human NHE3-mediated Na+-dependent H+ antiport was measured using a modification of the pH sensiti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2026
Entry Details US Patent

TargetHistone deacetylase 6(Human)
Chong Kun Dang Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 619648BDBM619648(US12570646, Compound 4 | US20230295142, Compound 4)
Affinity DataIC50: 99nMAssay Description:A HDAC enzyme inhibitory capacity of a test material was measured by using HDAC1 Fluorimetric Drug Discovery Assay Kit (Enzolifesciences: BML-AK511) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetHistone deacetylase 6(Human)
Chong Kun Dang Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 619648BDBM619648(US12570646, Compound 4 | US20230295142, Compound 4)
Affinity DataIC50: 147nMAssay Description:A HDAC enzyme inhibitory capacity of a test material was measured by using HDAC1 Fluorimetric Drug Discovery Assay Kit (Enzolifesciences: BML-AK511) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetHistone deacetylase 1(Human)
Chong Kun Dang Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 619648BDBM619648(US12570646, Compound 4 | US20230295142, Compound 4)
Affinity DataIC50: 1.00E+4nMAssay Description:Cell-based activity under Prompt Conditions. Rat or human NHE3-mediated Na+-dependent H+ antiport was measured using a modification of the pH sensiti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2026
Entry Details US Patent

TargetHistone deacetylase 1(Human)
Chong Kun Dang Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 619648BDBM619648(US12570646, Compound 4 | US20230295142, Compound 4)
Affinity DataIC50: 1.00E+4nMAssay Description:A HDAC enzyme inhibitory capacity of a test material was measured by using HDAC1 Fluorimetric Drug Discovery Assay Kit (Enzolifesciences: BML-AK511) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetHistone deacetylase 1(Human)
Chong Kun Dang Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 619648BDBM619648(US12570646, Compound 4 | US20230295142, Compound 4)
Affinity DataIC50: 1.00E+4nMAssay Description:A HDAC enzyme inhibitory capacity of a test material was measured by using HDAC1 Fluorimetric Drug Discovery Assay Kit (Enzolifesciences: BML-AK511) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent