BDBM619767 US20230295157, Example 90

SMILES Nc1nccc(-c2cnc([nH]2)[C@@H]2CC[C@@H]3CC(=CC(=O)N23)c2cc(Cl)ccc2-n2cnnn2)c1F

InChI Key InChIKey=MIGLERBRGFKCDU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 619767   

TargetCoagulation factor XI(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM619767(US20230295157, Example 90)
Affinity DataIC50: 0.5nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetKallikrein-1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM619767(US20230295157, Example 90)
Affinity DataIC50: 5.5nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of human plasma kallikrein. The peptide substrate, Z-Gly-Pro-Arg-AMC (Pur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent