BDBM619801 (3S,8aR)-3-(4-(6-amino-2-fluoropyridin-3-yl-5-d)-1H-imidazol-2-yl)-7-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl-5-d)-2,3,8,8a-tetrahydroindolizin-5(1H)-one::US20230295157, Example 125::US20230295157, Example 153

SMILES Nc1ccc(-c2c[nH]c(n2)[C@@H]2CC[C@@H]3CC(=CC(=O)N23)c2c(F)c(Cl)ccc2-n2cnnn2)c(F)n1

InChI Key InChIKey=BKRAEFSPBOVKHB-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 619801   

TargetCoagulation factor XI(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM619801((3S,8aR)-3-(4-(6-amino-2-fluoropyridin-3-yl-5-d)-1...)
Affinity DataIC50: 0.5nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetCoagulation factor XI(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM619801((3S,8aR)-3-(4-(6-amino-2-fluoropyridin-3-yl-5-d)-1...)
Affinity DataIC50: 0.5nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetKallikrein-1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM619801((3S,8aR)-3-(4-(6-amino-2-fluoropyridin-3-yl-5-d)-1...)
Affinity DataIC50: 8.10nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of human plasma kallikrein. The peptide substrate, Z-Gly-Pro-Arg-AMC (Pur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetKallikrein-1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM619801((3S,8aR)-3-(4-(6-amino-2-fluoropyridin-3-yl-5-d)-1...)
Affinity DataIC50: 9.60nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of human plasma kallikrein. The peptide substrate, Z-Gly-Pro-Arg-AMC (Pur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent