BDBM619906 (3S,8aR)-7-(3-Chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)-3-(5-(4-(trifluoromethyl)-1H-pyrrol-3-yl)-1H-imidazol-2-yl)-2,3,8,8a-tetrahydroindolizin-5(1H)-one::US20230295157, Example 230

SMILES Fc1c(Cl)ccc(c1C1=CC(=O)N2[C@H](CC[C@H]2c2ncc([nH]2)-c2c[nH]cc2C(F)(F)F)C1)-n1cnnn1

InChI Key InChIKey=AQJXAFPWULDCCN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 619906   

TargetCoagulation factor XI(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM619906(US20230295157, Example 230 | (3S,8aR)-7-(3-Chloro-...)
Affinity DataIC50: 0.400nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetKallikrein-1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM619906(US20230295157, Example 230 | (3S,8aR)-7-(3-Chloro-...)
Affinity DataIC50: 11.1nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of human plasma kallikrein. The peptide substrate, Z-Gly-Pro-Arg-AMC (Pur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent