BDBM620425 US11767305, Compound S-5-MBPB::US20250019357, Compound (+)-BK-5MBPB

SMILES CC[C@H](NC)C(=O)c1ccc2occc2c1

InChI Key InChIKey=QWIVHMKZSQEQGL-UHFFFAOYSA-N

Data  1 KI  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 620425   

TargetSodium-dependent serotonin transporter(Human)
Tactogen

US Patent
LigandPNGBDBM620425(US11767305, Compound S-5-MBPB | US20250019357, Com...)
Affinity DataIC50: 124nMAssay Description:For the SERT uptake inhibition assay, 5 nM [3H]5-HT was used. To optimize uptake for a single transporter, unlabeled blockers were included to preven...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2023
Entry Details
Go to US Patent

Target5-hydroxytryptamine receptor 1B(Rat)
Tactogen

US Patent
LigandPNGBDBM620425(US11767305, Compound S-5-MBPB | US20250019357, Com...)
Affinity DataEC50: >3.00E+4nMAssay Description:The 5-HT1BR cAMP secondary messenger agonist assay used a panel of CHO-K1 cell lines stably expressing non-tagged GPCRs that endogenously signal thro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2025
Entry Details
Go to US Patent

TargetSodium-dependent serotonin transporter(Human)
Tactogen

US Patent
LigandPNGBDBM620425(US11767305, Compound S-5-MBPB | US20250019357, Com...)
Affinity DataIC50: 6.50E+3nMAssay Description:Benzofuran derivatives were evaluated for inhibiting the human 5-HT transporter (hSERT) as expressed in CHO cells using an antagonist radioligand ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2025
Entry Details
Go to US Patent

TargetSodium-dependent serotonin transporter(Human)
Tactogen

US Patent
LigandPNGBDBM620425(US11767305, Compound S-5-MBPB | US20250019357, Com...)
Affinity DataKi:  3.00E+3nMAssay Description:Benzofuran derivatives were evaluated for inhibiting the human 5-HT transporter (hSERT) as expressed in CHO cells using an antagonist radioligand ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2025
Entry Details
Go to US Patent