BDBM621005 N-cyclopentyl-6-(5-fluoro-2-((5-(piperazine-1 -ylmethyl)pyridine-2-yl)amino)pyrimidine-4-yl)benzothiazole-2-amine hydrochloride::US20230303553, Example 21

SMILES Fc1cnc(Nc2ccc(CN3CCNCC3)cn2)nc1-c1ccc2nc(NC3CCCC3)sc2c1

InChI Key InChIKey=AUSDRYPYNGBOOX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 621005   

TargetCyclin-dependent kinase 6(Human)
Jiangsu Tasly Diyi Pharmaceutical

US Patent
LigandPNGBDBM621005(US20230303553, Example 21 | N-cyclopentyl-6-(5-flu...)
Affinity DataIC50: 201nMAssay Description:Table 1: In the test plate, protein kinase, Ulight-labeled polypeptide substrate, ATP, and the compounds were mixed and the reaction was incubated. E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
Go to US Patent

TargetDual specificity tyrosine-phosphorylation-regulated kinase 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM621005(US20230303553, Example 21 | N-cyclopentyl-6-(5-flu...)
Affinity DataIC50: 688nMAssay Description:Inhibition of DYRK2 (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed