BDBM621026 N-cyclopentyl-6-(5-fluoro-2-((5-((4-isopropylpiperazine-1-yl)methyl)pyridine-2-yl)amino)pyrimidine-4-yl)benzothiazole-2-amine::US20230303553, Example 28

SMILES CC(C)N1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3ccc4nc(NC5CCCC5)sc4c3)nc2)CC1

InChI Key InChIKey=JYRRTOFZIGEMAN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 621026   

TargetCyclin-dependent kinase 6(Human)
Jiangsu Tasly Diyi Pharmaceutical

US Patent
LigandPNGBDBM621026(US20230303553, Example 28 | N-cyclopentyl-6-(5-flu...)
Affinity DataIC50: 132nMAssay Description:Table 1: In the test plate, protein kinase, Ulight-labeled polypeptide substrate, ATP, and the compounds were mixed and the reaction was incubated. E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
Go to US Patent

TargetDual specificity tyrosine-phosphorylation-regulated kinase 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM621026(US20230303553, Example 28 | N-cyclopentyl-6-(5-flu...)
Affinity DataIC50: 647nMAssay Description:Inhibition of DYRK2 (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed