BDBM621040 5-fluoro-4-(2-methylbenzothiazole-6-yl)-N-(5-(piperazine-1 -ylmethyl)pyridine-2-yl)pyrimidine-2-amine hydrochloride::US20230303553, Example 15

SMILES Cc1nc2ccc(cc2s1)-c1nc(Nc2ccc(CN3CCNCC3)cn2)ncc1F

InChI Key InChIKey=BXPPINFBXDOAPI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 621040   

TargetCyclin-dependent kinase 6(Human)
Jiangsu Tasly Diyi Pharmaceutical

US Patent
LigandPNGBDBM621040(US20230303553, Example 15 | 5-fluoro-4-(2-methylbe...)
Affinity DataIC50: 464nMAssay Description:Table 1: In the test plate, protein kinase, Ulight-labeled polypeptide substrate, ATP, and the compounds were mixed and the reaction was incubated. E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
Go to US Patent

TargetDual specificity tyrosine-phosphorylation-regulated kinase 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM621040(US20230303553, Example 15 | 5-fluoro-4-(2-methylbe...)
Affinity DataIC50: 242nMAssay Description:Inhibition of DYRK2 (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed