BDBM621048 N,N-diethyl-6-(5-fluoro-2-((5-(piperazine-1 -yl)pyridine-2-yl)amino)pyrimidine-4-yl)benzothiazole-2-amine hydrochloride::US20230303553, Example 53

SMILES CCN(CC)c1nc2ccc(cc2s1)-c1nc(Nc2ccc(cn2)N2CCNCC2)ncc1F

InChI Key InChIKey=IQPGVUQARGVQGU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 621048   

TargetCyclin-dependent kinase 6(Human)
Jiangsu Tasly Diyi Pharmaceutical

US Patent
LigandPNGBDBM621048(US20230303553, Example 53 | N,N-diethyl-6-(5-fluor...)
Affinity DataIC50: 23nMAssay Description:Table 1: In the test plate, protein kinase, Ulight-labeled polypeptide substrate, ATP, and the compounds were mixed and the reaction was incubated. E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
Go to US Patent

TargetDual specificity tyrosine-phosphorylation-regulated kinase 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM621048(US20230303553, Example 53 | N,N-diethyl-6-(5-fluor...)
Affinity DataIC50: 134nMAssay Description:Inhibition of DYRK2 (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed