BDBM6218 AZD0530 analogue 34::Chlorobenzodioxole deriv. 27::N-(5-chloro-2H-1,3-benzodioxol-4-yl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine

SMILES COc1cc2c(Nc3c4OCOc4ccc3Cl)ncnc2cc1OCC1CCN(C)CC1

InChI Key InChIKey=UYKYCBACTCRLLP-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 6218   

LigandPNGBDBM6218(AZD0530 analogue 34 | N-(5-chloro-2H-1,3-benzodiox...)
Affinity DataIC50: 1.56E+4nMAssay Description:This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2005
Entry Details Article
PubMed
LigandPNGBDBM6218(AZD0530 analogue 34 | N-(5-chloro-2H-1,3-benzodiox...)
Affinity DataIC50: 5nMT: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-RRTK activity. The compounds were incubated with enzyme 20 min at room ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2005
Entry Details Article
PubMed
LigandPNGBDBM6218(AZD0530 analogue 34 | N-(5-chloro-2H-1,3-benzodiox...)
Affinity DataIC50: 1.00E+5nMAssay Description:This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2005
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Astrazeneca

LigandPNGBDBM6218(AZD0530 analogue 34 | N-(5-chloro-2H-1,3-benzodiox...)
Affinity DataIC50: 1.00E+5nMAssay Description:This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2005
Entry Details Article
PubMed
LigandPNGBDBM6218(AZD0530 analogue 34 | N-(5-chloro-2H-1,3-benzodiox...)
Affinity DataIC50: 5nMAssay Description:This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2006
Entry Details Article
PubMed