BDBM626326 7-(4-isopropylphenyl)-5-[(2- methylene-3-oxo-butyl)amino]-2,3- dihydrobenzofuran-4-carbonitrile::US11787775, Compound 11

SMILES CC(C)c1ccc(cc1)-c1cc(NCC(=C)C(C)=O)c(C#N)c2CCOc12

InChI Key InChIKey=FHUMCYQSYHHMDU-UHFFFAOYSA-N

Data  4 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 626326   

TargetTranscriptional enhancer factor TEF-1(Human)
Genentech

US Patent
LigandPNGBDBM626326(7-(4-isopropylphenyl)-5-[(2- methylene-3-oxo-buty...)
Affinity DataIC50: 180nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
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TargetTranscriptional enhancer factor TEF-4(Human)
Genentech

US Patent
LigandPNGBDBM626326(7-(4-isopropylphenyl)-5-[(2- methylene-3-oxo-buty...)
Affinity DataIC50: 80nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
Go to US Patent

TargetTranscriptional enhancer factor TEF-5(Human)
Genentech

US Patent
LigandPNGBDBM626326(7-(4-isopropylphenyl)-5-[(2- methylene-3-oxo-buty...)
Affinity DataIC50: 130nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
Go to US Patent

TargetTranscriptional enhancer factor TEF-3(Human)
Genentech

US Patent
LigandPNGBDBM626326(7-(4-isopropylphenyl)-5-[(2- methylene-3-oxo-buty...)
Affinity DataIC50: 40nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
Go to US Patent

LigandPNGBDBM626326(7-(4-isopropylphenyl)-5-[(2- methylene-3-oxo-buty...)
Affinity DataEC50:  320nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
Go to US Patent

LigandPNGBDBM626326(7-(4-isopropylphenyl)-5-[(2- methylene-3-oxo-buty...)
Affinity DataEC50:  130nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
Go to US Patent

LigandPNGBDBM626326(7-(4-isopropylphenyl)-5-[(2- methylene-3-oxo-buty...)
Affinity DataEC50:  200nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
Go to US Patent

LigandPNGBDBM626326(7-(4-isopropylphenyl)-5-[(2- methylene-3-oxo-buty...)
Affinity DataEC50:  80nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
Go to US Patent