BDBM626352 2-[[[4-(hydroxymethyl)-7-[4- (trifluoromethoxy)phenyl]-2,3- dihydrobenzofuran-5- yl]amino]methyl]prop-2-enamide::US11787775, Compound 35

SMILES NC(=O)C(=C)CNc1cc(c2OCCc2c1CO)-c1ccc(OC(F)(F)F)cc1

InChI Key InChIKey=IWIKYJBGAPPILP-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 626352   

TargetTranscriptional enhancer factor TEF-4(Human)
Genentech

US Patent
LigandPNGBDBM626352(2-[[[4-(hydroxymethyl)-7-[4- (trifluoromethoxy)ph...)
Affinity DataIC50: 30nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

LigandPNGBDBM626352(2-[[[4-(hydroxymethyl)-7-[4- (trifluoromethoxy)ph...)
Affinity DataIC50: 60nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetTranscriptional enhancer factor TEF-1(Human)
Genentech

US Patent
LigandPNGBDBM626352(2-[[[4-(hydroxymethyl)-7-[4- (trifluoromethoxy)ph...)
Affinity DataIC50: 160nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetTranscriptional enhancer factor TEF-3(Human)
Genentech

US Patent
LigandPNGBDBM626352(2-[[[4-(hydroxymethyl)-7-[4- (trifluoromethoxy)ph...)
Affinity DataIC50: 250nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

LigandPNGBDBM626352(2-[[[4-(hydroxymethyl)-7-[4- (trifluoromethoxy)ph...)
Affinity DataIC50: 410nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

LigandPNGBDBM626352(2-[[[4-(hydroxymethyl)-7-[4- (trifluoromethoxy)ph...)
Affinity DataIC50: 590nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetTranscriptional enhancer factor TEF-5(Human)
Genentech

US Patent
LigandPNGBDBM626352(2-[[[4-(hydroxymethyl)-7-[4- (trifluoromethoxy)ph...)
Affinity DataIC50: 1.70E+3nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

LigandPNGBDBM626352(2-[[[4-(hydroxymethyl)-7-[4- (trifluoromethoxy)ph...)
Affinity DataIC50: 3.30E+3nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent