BDBM626355 2-[[[4-cyano-7-[4-(pentafluoro- lambda6-sulfanyl)phenyl]-2,3- dihydrobenzofuran-5- yl]amino]methyl]prop-2- enehydroxamic acid::US11787775, Compound 38

SMILES ONC(=O)C(=C)CNc1cc(c2OCCc2c1C#N)-c1ccc(cc1)S(F)(F)(F)(F)F

InChI Key InChIKey=DGLKNRDFMZDACB-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 626355   

TargetTranscriptional enhancer factor TEF-4(Human)
Genentech

US Patent
LigandPNGBDBM626355(2-[[[4-cyano-7-[4-(pentafluoro- lambda6-sulfanyl)...)
Affinity DataIC50: 30nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

LigandPNGBDBM626355(2-[[[4-cyano-7-[4-(pentafluoro- lambda6-sulfanyl)...)
Affinity DataIC50: 50nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetTranscriptional enhancer factor TEF-3(Human)
Genentech

US Patent
LigandPNGBDBM626355(2-[[[4-cyano-7-[4-(pentafluoro- lambda6-sulfanyl)...)
Affinity DataIC50: 80nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetTranscriptional enhancer factor TEF-1(Human)
Genentech

US Patent
LigandPNGBDBM626355(2-[[[4-cyano-7-[4-(pentafluoro- lambda6-sulfanyl)...)
Affinity DataIC50: 90nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

LigandPNGBDBM626355(2-[[[4-cyano-7-[4-(pentafluoro- lambda6-sulfanyl)...)
Affinity DataIC50: 100nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

LigandPNGBDBM626355(2-[[[4-cyano-7-[4-(pentafluoro- lambda6-sulfanyl)...)
Affinity DataIC50: 160nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetTranscriptional enhancer factor TEF-5(Human)
Genentech

US Patent
LigandPNGBDBM626355(2-[[[4-cyano-7-[4-(pentafluoro- lambda6-sulfanyl)...)
Affinity DataIC50: 710nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

LigandPNGBDBM626355(2-[[[4-cyano-7-[4-(pentafluoro- lambda6-sulfanyl)...)
Affinity DataIC50: 970nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent