BDBM626365 2-[[[7-cyano-4-[4-(pentafluoro- lambda6-sulfanyl)phenyl]-1,3- benzothiazol-6- yl]amino]methyl]prop-2- enehydroxamic acid::US11787775, Compound 51

SMILES ONC(=O)C(=C)CNc1cc(-c2ccc(cc2)S(F)(F)(F)(F)F)c2ncsc2c1C#N

InChI Key InChIKey=DJGXOJSWOLDZPW-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 626365   

LigandPNGBDBM626365(2-[[[7-cyano-4-[4-(pentafluoro- lambda6-sulfanyl)...)
Affinity DataIC50: 30nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetTranscriptional enhancer factor TEF-4(Human)
Genentech

US Patent
LigandPNGBDBM626365(2-[[[7-cyano-4-[4-(pentafluoro- lambda6-sulfanyl)...)
Affinity DataIC50: 30nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetTranscriptional enhancer factor TEF-3(Human)
Genentech

US Patent
LigandPNGBDBM626365(2-[[[7-cyano-4-[4-(pentafluoro- lambda6-sulfanyl)...)
Affinity DataIC50: 60nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetTranscriptional enhancer factor TEF-1(Human)
Genentech

US Patent
LigandPNGBDBM626365(2-[[[7-cyano-4-[4-(pentafluoro- lambda6-sulfanyl)...)
Affinity DataIC50: 200nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

LigandPNGBDBM626365(2-[[[7-cyano-4-[4-(pentafluoro- lambda6-sulfanyl)...)
Affinity DataIC50: 210nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetTranscriptional enhancer factor TEF-5(Human)
Genentech

US Patent
LigandPNGBDBM626365(2-[[[7-cyano-4-[4-(pentafluoro- lambda6-sulfanyl)...)
Affinity DataIC50: 1.20E+3nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

LigandPNGBDBM626365(2-[[[7-cyano-4-[4-(pentafluoro- lambda6-sulfanyl)...)
Affinity DataIC50: 1.70E+3nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

LigandPNGBDBM626365(2-[[[7-cyano-4-[4-(pentafluoro- lambda6-sulfanyl)...)
Affinity DataIC50: 5.00E+4nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent