BDBM629234 3-[1-(4-fluoro-3-methyl-phenyl)-5-hydroxy-2-isopropyl-indol-3-yl]cyclobutanecarbonitrile (215)::US20230339915, Compound 215

SMILES CC(C)c1c([C@@H]2C[C@@H](C2)C#N)c2cc(O)ccc2n1-c1ccc(F)c(C)c1

InChI Key InChIKey=CRBXSRPTBIMVPG-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 629234   

TargetAlpha-1-antitrypsin(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM629234(US20230339915, Compound 215 | 3-[1-(4-fluoro-3-met...)
Affinity DataIC50: 5.00E+3nMAssay Description:Assay Protocol: Pre-Incubation of Z-AAT with Compounds1. 7.5 μL of Z-AAT (20 nM) was incubated with compounds 1-227 in a GCA plate for 1 hour at...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
Go to US Patent