BDBM631468 US20230348424, Example 51

SMILES C[C@@H](NC(=O)c1cn(c(=O)cc1NC1CCN(C)CC1)C1(CC1)C(F)F)c1cccc(c1F)C(C)(F)F

InChI Key InChIKey=ZBFAZPBBZRKBNE-UHFFFAOYSA-N

Data  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 631468   

LigandPNGBDBM631468(US20230348424, Example 51)
Affinity DataIC50: 18.5nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2023
Entry Details
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TargetSon of sevenless homolog 1 [564-1049]()
SchröDinger

US Patent
LigandPNGBDBM631468(US20230348424, Example 51)
Affinity DataKd:  8nMAssay Description:Binding to SOS1 was measured using a SPR assay with purified recombinant human SOS1 substrate (res. 564-1049 with N-terminal Avi tag; purified and bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2023
Entry Details
Go to US Patent