BDBM631506 US20230348424, Example 89

SMILES C[C@@H](NC(=O)c1cn(c(=O)cc1N[C@@H]1[C@H]2CNC[C@@H]12)C12CC(C1)C2)c1cccc(C(F)F)c1F

InChI Key InChIKey=POZGXECZBAYTIO-UHFFFAOYSA-N

Data  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 631506   

LigandPNGBDBM631506(US20230348424, Example 89)
Affinity DataIC50: 22.9nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2023
Entry Details
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TargetSon of sevenless homolog 1 [564-1049]()
SchröDinger

US Patent
LigandPNGBDBM631506(US20230348424, Example 89)
Affinity DataKd:  12nMAssay Description:Binding to SOS1 was measured using a SPR assay with purified recombinant human SOS1 substrate (res. 564-1049 with N-terminal Avi tag; purified and bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2023
Entry Details
Go to US Patent