BDBM633146 Synthesis of (S)-N-(3,5-Difluoro-4-((1S,3R)-3-Methyl-2-(2,2,2-Trifluoroethyl)-2,3,4,9-Tetrahydro-1H-Pyridino[3,4-b]Indol-1-yl)Phenyl)-1-(3-Fluoropropyl)Pyrrolidin-3-Amine ::US20230348459, Example 4

SMILES C[C@@H]1Cc2c([nH]c3ccccc23)[C@H](N1CC(F)(F)F)c1c(F)cc(N[C@H]2CCN(CCCF)C2)cc1F

InChI Key InChIKey=HHOPFZCXWJZNIA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 633146   

TargetCytochrome P450 2C9(Human)
Simcere Pharmaceutical

US Patent
LigandPNGBDBM633146(US20230348459, Example 4 | Synthesis of (S)-N-(3,5...)
Affinity DataIC50: 2.00E+4nMAssay Description:I. Test Materials and Instruments1. Human liver microsomes (Corning 452117)2. NADPH (Solarbio 705Y021)3. Positive substrates diclofenac (Sigma SLBV34...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2023
Entry Details
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TargetCytochrome P450 2D6(Human)
Simcere Pharmaceutical

US Patent
LigandPNGBDBM633146(US20230348459, Example 4 | Synthesis of (S)-N-(3,5...)
Affinity DataIC50: 2.70E+4nMAssay Description:I. Test Materials and Instruments1. Human liver microsomes (Corning 452117)2. NADPH (Solarbio 705Y021)3. Positive substrates diclofenac (Sigma SLBV34...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2023
Entry Details
Go to US Patent