BDBM633288 US20190276450, Example 3

SMILES COCc1cc(nc(c1)[C@@]1(CCOC1)OC)-c1cn(C)c2cnc(NC(N)=O)cc12

InChI Key InChIKey=CHGXOFRVCIYFLT-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 633288   

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Abbvie

US Patent
LigandPNGBDBM633288(US20190276450, Example 3)
Affinity DataEC50:  35nMAssay Description:IL-12 is known to transduce its signal through IL-12 receptor via Jak2 and/or Tyk2. For that reason, the activity against Tyk2/Jak2 was measured by d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Abbvie

US Patent
LigandPNGBDBM633288(US20190276450, Example 3)
Affinity DataEC50:  1.80E+4nMAssay Description:IL-6 is known to transduce its signal through IL-6 receptor via Jak1. Activity against Jak was therefore measured by determining inhibition of IL-6 i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Abbvie

US Patent
LigandPNGBDBM633288(US20190276450, Example 3)
Affinity DataEC50: >2.50E+4nMAssay Description:Erythropoietin (EPO) is known to transduce its signal through EPO receptor via Jak2. Activity against Jak2 was therefore measured by determining inhi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2023
Entry Details
US Patent