BDBM633299 US20190276450, Example 6.2

SMILES CO[C@@]1(CCOC1)c1cc(OCC2COC2)cc(n1)-c1cn(C)c2cnc(NC(C)=O)cc12

InChI Key InChIKey=HZGWNWPLKLBPED-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 633299   

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Abbvie

US Patent
LigandPNGBDBM633299(US20190276450, Example 6.2)
Affinity DataEC50:  103nMAssay Description:IL-12 is known to transduce its signal through IL-12 receptor via Jak2 and/or Tyk2. For that reason, the activity against Tyk2/Jak2 was measured by d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Abbvie

US Patent
LigandPNGBDBM633299(US20190276450, Example 6.2)
Affinity DataEC50:  5.20E+3nMAssay Description:IL-6 is known to transduce its signal through IL-6 receptor via Jak1. Activity against Jak was therefore measured by determining inhibition of IL-6 i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2023
Entry Details
US Patent