BDBM633342 US20190276450, Example 20

SMILES COc1cc(nc(c1)[C@@]1(CCOC1)OC)-c1cn(C)c2cnc(NC(C)=O)cc12

InChI Key InChIKey=SXWCIACCEMZQQE-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 633342   

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Abbvie

US Patent
LigandPNGBDBM633342(US20190276450, Example 20)
Affinity DataEC50:  137nMAssay Description:IL-12 is known to transduce its signal through IL-12 receptor via Jak2 and/or Tyk2. For that reason, the activity against Tyk2/Jak2 was measured by d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Abbvie

US Patent
LigandPNGBDBM633342(US20190276450, Example 20)
Affinity DataEC50:  4.50E+4nMAssay Description:IL-6 is known to transduce its signal through IL-6 receptor via Jak1. Activity against Jak was therefore measured by determining inhibition of IL-6 i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2023
Entry Details
US Patent