BDBM633976 US11807649, Compound 51

SMILES CN(C)C\C=C\C(=O)N1CCN2C[C@H]1COc1cc3ncnc(Nc4ccc(Oc5cncc(F)c5)c(C)c4)c3nc21

InChI Key InChIKey=WLLHJVRLVANDFW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 633976   

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Enliven Therapeutics

US Patent
LigandPNGBDBM633976(US11807649, Compound 51)
Affinity DataIC50: 8.84nMAssay Description:Enzyme-linked immunosorbent assays (ELISA) were performed to measure phosphorylated ERBB2 levels. A capture antibody able to detect phosphorylated an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2023
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Enliven Therapeutics

US Patent
LigandPNGBDBM633976(US11807649, Compound 51)
Affinity DataIC50: 177nMAssay Description:Enzyme-linked immunosorbent assays (ELISA) were performed to measure phosphorylated EGFR levels using A431 cells (10% FBS). A431 (1.0*104 cells/40 &#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2023
Entry Details
US Patent