BDBM636130 (1R,2S)-5'-methoxy-2-(3-{[3-methoxy-5-(oxane-4-sulfonyl)pyridin-2-yl]amino}-1H-indazol-6-yl)spiro[cyclopropane-1,3'-indol]-2'(1'H)-one::US20230365537, Example 259

SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(Nc5ncc(cc5OC)S(=O)(=O)C5CCOCC5)n[nH]c4c3)c2c1

InChI Key InChIKey=VHIUYJBYHQFWHD-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 636130   

TargetSerine/threonine-protein kinase PLK4(Human)
Oric Pharmaceuticals

US Patent
LigandPNGBDBM636130(US20230365537, Example 259 | (1R,2S)-5'-methoxy-2-...)
Affinity DataIC50: 0.971nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2024
Entry Details
Go to US Patent

TargetAurora kinase A(Human)
Oric Pharmaceuticals

US Patent
LigandPNGBDBM636130(US20230365537, Example 259 | (1R,2S)-5'-methoxy-2-...)
Affinity DataIC50: 1.26E+3nMAssay Description:Activity of human recombinant Aurora A (ThermoFisher, cat #PR5935A) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo K...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2024
Entry Details
Go to US Patent

TargetAurora kinase B(Human)
Oric Pharmaceuticals

US Patent
LigandPNGBDBM636130(US20230365537, Example 259 | (1R,2S)-5'-methoxy-2-...)
Affinity DataIC50: 811nMAssay Description:Activity of human recombinant Aurora B (ThermoFisher, cat #PR9210B) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo K...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2024
Entry Details
Go to US Patent