BDBM636719 (S) N-(4-cyano-3-(trifluoromethyl)phenyl)-3-(4-((8R,9S)-5-fluoro-9-(1-methyl-1H-1,2,4-triazol-5-yl)-3-oxo-3,7,8,9-tetrahydro-2H-pyrido[4,3,2-de]phthalazin-8-yl)phenoxy)-2-hydroxy-2-methylpropanamide ::US11826430, Compound 1.1b

SMILES Cn1ncnc1[C@H]1[C@@H](Nc2cc(F)cc3c2c1n[nH]c3=O)c1ccc(OC[C@](C)(O)C(=O)Nc2ccc(C#N)c(c2)C(F)(F)F)cc1

InChI Key InChIKey=AROUQFRRWYAJHE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 636719   

TargetPoly [ADP-ribose] polymerase 1(Human)
Nuvation Bio

US Patent
LigandPNGBDBM636719((S) N-(4-cyano-3-(trifluoromethyl)phenyl)-3-(4-((8...)
Affinity DataIC50: 60nMAssay Description:i. PARP1 assay: Human recombinant PARP1 at a final concentration of 2.5 nM was combined with histone H4 (20 μM) and test articles at various con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2024
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 2(Human)
Nuvation Bio

US Patent
LigandPNGBDBM636719((S) N-(4-cyano-3-(trifluoromethyl)phenyl)-3-(4-((8...)
Affinity DataIC50: 30nMAssay Description:i. PARP1 assay: Human recombinant PARP1 at a final concentration of 2.5 nM was combined with histone H4 (20 μM) and test articles at various con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2024
Entry Details
Go to US Patent