BDBM636721 4-(3-(1-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoyl)piperidin-4-yl)-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile ::US11826430, Compound 1.3

SMILES CC1(C)N(C2CCN(CC2)C(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)ccc2F)C(=S)N(C1=O)c1ccc(C#N)c(c1)C(F)(F)F

InChI Key InChIKey=CHWBVGUNUQRUHT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 636721   

TargetPoly [ADP-ribose] polymerase 1(Human)
Nuvation Bio

US Patent
LigandPNGBDBM636721(4-(3-(1-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-...)
Affinity DataIC50: 3nMAssay Description:i. PARP1 assay: Human recombinant PARP1 at a final concentration of 2.5 nM was combined with histone H4 (20 μM) and test articles at various con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2024
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 2(Human)
Nuvation Bio

US Patent
LigandPNGBDBM636721(4-(3-(1-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-...)
Affinity DataIC50: 0.600nMAssay Description:i. PARP1 assay: Human recombinant PARP1 at a final concentration of 2.5 nM was combined with histone H4 (20 μM) and test articles at various con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2024
Entry Details
Go to US Patent