BDBM636725 N-(2-(5,5-dimethyl-3-(4-nitro-3-(trifluoromethyl)phenyl)-2,4-dioxoimidazolidin-1-yl)ethyl)-2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzamide ::US11826430, Compound 1.7

SMILES CC1(C)N(CCNC(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)ccc2F)C(=O)N(C1=O)c1ccc(c(c1)C(F)(F)F)[N+]([O-])=O

InChI Key InChIKey=NIOMTPKIOLNRTQ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 636725   

TargetPoly [ADP-ribose] polymerase 1(Human)
Nuvation Bio

US Patent
LigandPNGBDBM636725(N-(2-(5,5-dimethyl-3-(4-nitro-3-(trifluoromethyl)p...)
Affinity DataIC50: 7nMAssay Description:i. PARP1 assay: Human recombinant PARP1 at a final concentration of 2.5 nM was combined with histone H4 (20 μM) and test articles at various con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2024
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 2(Human)
Nuvation Bio

US Patent
LigandPNGBDBM636725(N-(2-(5,5-dimethyl-3-(4-nitro-3-(trifluoromethyl)p...)
Affinity DataIC50: 1nMAssay Description:i. PARP1 assay: Human recombinant PARP1 at a final concentration of 2.5 nM was combined with histone H4 (20 μM) and test articles at various con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2024
Entry Details
Go to US Patent

TargetAndrogen receptor(Human)
Nuvation Bio

US Patent
LigandPNGBDBM636725(N-(2-(5,5-dimethyl-3-(4-nitro-3-(trifluoromethyl)p...)
Affinity DataIC50: 4.62E+3nMAssay Description:AR in LNCaP cytosol was used for determining the binding affinity of test articles and the reference compound progesterone (Sigma, Cat: E2785, St. Lo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2024
Entry Details
Go to US Patent