BDBM636732 (E)-4-(3-(4-(2-(3-(4-(2-(4-chloro-2-fluorophenyl)-1-(1H-indazol-5-yl)but-1-enyl)phenoxy)propoxy)ethyl)piperazine-1-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-one ::US11826430, Compound 2.54

SMILES CC\C(=C(\c1ccc(OCCCOCCN2CCN(CC2)C(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)ccc2F)cc1)c1ccc2[nH]ncc2c1)c1ccc(Cl)cc1F

InChI Key InChIKey=NUHZJIJDJJVSKK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 636732   

TargetPoly [ADP-ribose] polymerase 1(Human)
Nuvation Bio

US Patent
LigandPNGBDBM636732((E)-4-(3-(4-(2-(3-(4-(2-(4-chloro-2-fluorophenyl)-...)
Affinity DataIC50: 40nMAssay Description:i. PARP1 assay: Human recombinant PARP1 at a final concentration of 2.5 nM was combined with histone H4 (20 μM) and test articles at various con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2024
Entry Details
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TargetPoly [ADP-ribose] polymerase 2(Human)
Nuvation Bio

US Patent
LigandPNGBDBM636732((E)-4-(3-(4-(2-(3-(4-(2-(4-chloro-2-fluorophenyl)-...)
Affinity DataIC50: 5nMAssay Description:i. PARP1 assay: Human recombinant PARP1 at a final concentration of 2.5 nM was combined with histone H4 (20 μM) and test articles at various con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2024
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Nuvation Bio

US Patent
LigandPNGBDBM636732((E)-4-(3-(4-(2-(3-(4-(2-(4-chloro-2-fluorophenyl)-...)
Affinity DataIC50: 64.1nMAssay Description:ERα binding was assessed by the LanthaScreen TR-FRET ER Alpha Competitive Binding Assay at Thermo Fisher. In this assay, a terbium-labeled anti-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2024
Entry Details
Go to US Patent