BDBM639298 1-(((R)-1-(2-cyanoacetyl)piperidin-3-yl)oxy)-4-(1-(trans-4-ethoxycyclohexyl)-1H-pyrazol-4-yl)-7-isopropoxyisoquinoline-6-carboxamide::US20230391748, Compound I-124

SMILES CCO[C@H]1CC[C@@H](CC1)n1cc(cn1)-c1cnc(O[C@@H]2CCCN(C2)C(=O)CC#N)c2cc(OC(C)C)c(cc12)C(N)=O

InChI Key InChIKey=QRUGXZVMURBHIB-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 639298   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM639298(1-(((R)-1-(2-cyanoacetyl)piperidin-3-yl)oxy)-4-(1-...)
Affinity DataIC50: 6.80nMAssay Description:The ADP-Glo reagents were thawed at ambient temperature. The Kinase Detection Reagent was prepared by mixing kinase detection buffer with the lyophil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent